15870
Fluka
Brefeldin A
BioChemika, ≥99.0% (TLC), from Penicillium brefeldianum
| Synonym: | Ascotoxin, BFA, Cyanein, Decumbin, γ,4-Dihydroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic acid λ-lactone |
| CAS Number: | 20350-15-6 |
| Linear Formula: | C16H24O4 |
| Molecular Weight: | 280.36 |
| Beilstein Registry Number: | 25191 |
| MDL number: | MFCD00083258 |
Description
| Other Notes | Effects a rapid increase of Golgi cisternae volume and subsequent loss of recognizable Golgi apparatus in treated cells1,2. |
| Biochem/physiol Actions | Brefeldin A (BFA) is a fungal metabolite which disrupts the structure and function of the Golgi apparatus. BFA is an activator of the sphingomyelin cycle. Brefeldin A-mediated apoptosis has been observed in human tumor cells. |
Properties
| biological source | from Penicillium brefeldianum |
| product line | BioChemika |
| assay | ≥99.0% (TLC) |
| mp | 200-205 °C |
| solubility | methanol: 10 mg/mL, clear, colorless to faintly yellow |
| storage temp. | 2-8°C |
Safety
| Personal Protective Equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| RIDADR | UN2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | GY8410000 |
Related Products
| Replaced by | B7651, Brefeldin A |
